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Cell biology
At the time I began college, biology would have been at the bottom of a list of potential majors. I enrolled in a physical an¬thropology course to fulfill the life science requirement by the easiest possible route. During that course, I learned for the first time about chromosomes, mitosis, and genetic recombi¬nation, and I became fascinated by the intricate activities that could take place in such a small volume of cellular space. The next semester, I took Introductory Biology and began to seri¬ously consider becoming a cell biologist. I am burdening you with this personal trivia so you will understand why I wrote this book and to warn you of possible repercussions.
Even though many years have passed, I still find cell biol¬ogy the most fascinating subject to explore, and I still love spending the day reading about the latest findings by col¬leagues in the field. Thus, for me, writing a text on cell biology provides a reason and an opportunity to keep abreast with what is going on throughout the field. My primary goal in writing this text is to help generate an appreciation in students for the activities in which the giant molecules and minuscule structures that inhabit the cellular world of life are engaged. Another goal is to provide the reader with an insight into the types of questions that cell and molecular biologists ask and the experimental approaches they use to seek answers. As you read the text, think like a researcher; consider the "evidence that is presented, think of alternate explanations, plan experi¬ments that could lead to new hypotheses.
You might begin this approach by looking at one of the many electron micrographs that fill the pages of this text. To take this photograph, you would be sitting in a small, pitch-black room in front of a large metallic instrument whose col¬umn rises several meters above your head. You are looking through a pair of binoculars at a vivid,'bright green screen. The parts of the cell you are examining appear dark and color¬less against the bright green background. They are dark be¬cause they've been stained with heavy metal atoms that deflect a fraction of the electrons within a beam that is being focused on the viewing screen by large electromagnetic lenses in the wall of the column. The electrons that strike the screen are ac¬celerated through the evacuated space of the column by a force ot tens of thousands of volts. One of your hands may be grip¬ping a knob that controls the magnifying power of the lenses. A simple turn of this knob can switch the image in front of your eyes from that of a whole field of cells to a tiny part of a cell, such as a few ribosomes or a small portion of a single membrane. By turning other knobs, you can watch different parts of the specimen glide across the screen, giving you the sensation that you're driving around inside a cell.
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